KEGG   Homo sapiens (human): 65268
Entry
65268             CDS       T01001                                 
Symbol
WNK2, NY-CO-43, P/OKcl.13, PRKWNK2, SDCCAG43
Name
(RefSeq) WNK lysine deficient protein kinase 2
  KO
K08867  WNK lysine deficient protein kinase [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04928  Parathyroid hormone synthesis, secretion and action
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    65268 (WNK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    65268 (WNK2)
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    65268 (WNK2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     65268 (WNK2)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: Other
  Wnk family
   65268 (WNK2)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     65268 (WNK2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr OSR1_C
Other DBs
NCBI-GeneID: 65268
NCBI-ProteinID: NP_001269323
OMIM: 606249
HGNC: 14542
Ensembl: ENSG00000165238
UniProt: Q9Y3S1
Structure
Position
9:93184139..93320569
AA seq 2297 aa
MDGDGGRRDVPGTLMEPGRGAGPAGMAEPRAKAARPGPQRFLRRSVVESDQEEPPGLEAA
EAPGPQPPQPLQRRVLLLCKTRRLIAERARGRPAAPAPAALVAQPGAPGAPADAGPEPVG
TQEPGPDPIAAAVETAPAPDGGPREEAAATVRKEDEGAAEAKPEPGRTRRDEPEEEEDDE
DDLKAVATSLDGRFLKFDIELGRGSFKTVYKGLDTETWVEVAWCELQDRKLTKLERQRFK
EEAEMLKGLQHPNIVRFYDFWESSAKGKRCIVLVTELMTSGTLKTYLKRFKVMKPKVLRS
WCRQILKGLLFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRASFAKSVIGT
PEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTCGIKPASFEK
VHDPEIKEIIGECICKNKEERYEIKDLLSHAFFAEDTGVRVELAEEDHGRKSTIALRLWV
EDPKKLKGKPKDNGAIEFTFDLEKETPDEVAQEMIESGFFHESDVKIVAKSIRDRVALIQ
WRRERIWPALQPKEQQDVGSPDKARGPPVPLQVQVTYHAQAGQPGPPEPEEPEADQHLLP
PTLPTSATSLASDSTFDSGQGSTVYSDSQSSQQSVMLGSLADAAPSPAQCVCSPPVSEGP
VLPQSLPSLGAYQQPTAAPGLPVGSVPAPACPPSLQQHFPDPAMSFAPVLPPPSTPMPTG
PGQPAPPGQQPPPLAQPTPLPQVLAPQPVVPLQPVPPHLPPYLAPASQVGAPAQLKPLQM
PQAPLQPLAQVPPQMPPIPVVPPITPLAGIDGLPPALPDLPTATVPPVPPPQYFSPAVIL
PSLAAPLPPASPALPLQAVKLPHPPGAPLAMPCRTIVPNAPATIPLLAVAPPGVAALSIH
SAVAQLPGQPVYPAAFPQMAPTDVPPSPHHTVQNMRATPPQPALPPQPTLPPQPVLPPQP
TLPPQPVLPPQPTRPPQPVLPPQPMLPPQPVLPPQPALPVRPEPLQPHLPEQAAPAATPG
SQILLGHPAPYAVDVAAQVPTVPVPPAAVLSPPLPEVLLPAAPELLPQFPSSLATVSASV
QSVPTQTATLLPPANPPLPGGPGIASPCPTVQLTVEPVQEEQASQDKPPGLPQSCESYGG
SDVTSGKELSDSCEGAFGGGRLEGRAARKHHRRSTRARSRQERASRPRLTILNVCNTGDK
MVECQLETHNHKMVTFKFDLDGDAPDEIATYMVEHDFILQAERETFIEQMKDVMDKAEDM
LSEDTDADRGSDPGTSPPHLSTCGLGTGEESRQSQANAPVYQQNVLHTGKRWFIICPVAE
HPAPEAPESSPPLPLSSLPPEASQGPCRGLTLPCLPWRRAACGAVFLSLFSAESAQSKQP
PDSAPYKDQLSSKEQPSFLASQQLLSQAGPSNPPGAPPAPLAPSSPPVTALPQDGAAPAT
STMPEPASGTASQAGGPGTPQGLTSELETSQPLAETHEAPLAVQPLVVGLAPCTPAPEAA
STRDASAPREPLPPPAPEPSPHSGTPQPALGQPAPLLPAAVGAVSLATSQLPSPPLGPTV
PPQPPSALESDGEGPPPRVGFVDSTIKSLDEKLRTLLYQEHVPTSSASAGTPVEVGDRDF
TLEPLRGDQPRSEVCGGDLALPPVPKEAVSGRVQLPQPLVEKSELAPTRGAVMEQGTSSS
MTAESSPRSMLGYDRDGRQVASDSHVVPSVPQDVPAFVRPARVEPTDRDGGEAGESSAEP
PPSDMGTVGGQASHPQTLGARALGSPRKRPEQQDVSSPAKTVGRFSVVSTQDEWTLASPH
SLRYSAPPDVYLDEAPSSPDVKLAVRRAQTASSIEVGVGEPVSSDSGDEGPRARPPVQKQ
ASLPVSGSVAGDFVKKATAFLQRPSRAGSLGPETPSRVGMKVPTISVTSFHSQSSYISSD
NDSELEDADIKKELQSLREKHLKEISELQSQQKQEIEALYRRLGKPLPPNVGFFHTAPPT
GRRRKTSKSKLKAGKLLNPLVRQLKVVASSTGHLADSSRGPPAKDPAQASVGLTADSTGL
SGKAVQTQQPCSVRASLSSDICSGLASDGGGARGQGWTVYHPTSERVTYKSSSKPRARFL
SGPVSVSIWSALKRLCLGKEHSSRSSTSSLAPGPEPGPQPALHVQAQVNNSNNKKGTFTD
DLHKLVDEWTSKTVGAAQLKPTLNQLKQTQKLQDMEAQAGWAAPGEARAMTAPRAGVGMP
RLPPAPGPLSTTVIPGAAPTLSVPTPDGALGTARRNQVWFGLRVPPTACCGHSTQPRGGQ
RVGSKTASFAASDPVRS
NT seq 6894 nt   +upstreamnt  +downstreamnt
atggacggcgatggcggccgccgagacgtccccggcacgctgatggagcccgggcgcggc
gcggggcccgcgggcatggcggagcctcgggcgaaggcggcgcggccggggccccagcgc
tttctgcggcgcagcgtggtagagtcggaccaggaggagccgccgggcttggaggcagcc
gaggcgccgggcccgcagcccccgcagcccctgcagcgccgggtgcttctgctctgcaag
acgcgccgcctcatcgcggagcgcgcccgcggacgccccgccgcccccgcgcccgcagcg
ctggtagcgcagccgggagcccccggagcccccgcggacgccggccccgagcccgtgggc
acgcaggagcccggcccggaccccatcgcagccgctgtcgaaaccgcgcctgcccccgac
ggcggccccagggaggaggcggcggcgaccgtgaggaaggaggatgagggggcggccgag
gcgaagcctgagcccgggcgcactcgccgggacgagcccgaagaggaggaggacgacgag
gacgacctcaaggccgtggccacctctctggacggccgcttcctcaagttcgacatcgag
ctgggccgcggttccttcaagacggtctacaaggggctggacacggagacctgggtggag
gtggcctggtgtgagctgcaggaccggaagctcaccaagctggagcggcagcggttcaag
gaagaggctgagatgctgaaaggcctgcagcaccccaacatcgtgcgcttctacgacttc
tgggagtccagcgccaagggcaagcggtgcattgtgctggtgacggagctgatgacctca
gggacgctgaagacatacctgaagcggttcaaggtgatgaagcccaaggttctccgcagc
tggtgccggcagatcctgaagggcctgctgttcctgcacacaaggacgccacccatcatc
caccgagacctgaaatgtgacaatattttcatcaccggaccaactgggtctgtgaagatt
ggcgacttgggcctggccactctgaaaagagcgtcatttgccaaaagtgtgataggtact
cccgagttcatggcgcccgagatgtacgaggagcactacgatgagtccgtggacgtctat
gcctttgggatgtgcatgctggagatggccacctcggagtacccctactcggagtgccag
aatgcggcccagatctaccgcaaggtcacctgtggtatcaagccggccagctttgagaaa
gtgcacgatcctgaaatcaaggagattattggggagtgtatctgcaaaaacaaggaggaa
aggtacgagatcaaagacctgctgagccacgccttcttcgcagaggacacaggcgtgagg
gtggagctcgcggaggaggaccacggcaggaagtccaccatcgccctgaggctctgggtg
gaagaccccaagaaactgaagggaaagcccaaggacaatggagccatagagttcaccttc
gacctggagaaggagacgccggatgaggtggcccaagagatgattgagtctggattcttc
cacgagagtgacgtcaagatcgtggccaagtccatccgtgaccgcgtggccttgatccag
tggcggcgggagaggatctggcccgcgctgcagcccaaggagcagcaggatgtgggcagc
ccggacaaggccaggggtccgccggtgcccctgcaggtccaggtgacctaccatgcacag
gctgggcagcccgggccaccagagcccgaggagccggaggccgaccagcacctcctgcca
cctacgttgccgaccagcgccacctccctggcctcggacagcaccttcgacagcggccag
ggctctaccgtgtactcagactcgcagagcagccagcagagcgtgatgcttggctccctt
gccgacgcagcgccgtccccggcccagtgtgtgtgcagcccccctgtgagcgaggggccc
gtcctgccgcagagcctgccctcgctgggggcctaccagcagcccacggctgcacctggc
ttgccggtgggctctgtcccggcccccgcctgccctccgtccctccagcagcacttcccg
gatccggccatgagcttcgcccccgtgctgccgccgcccagcacccccatgcccacgggc
ccaggccagccagcaccccccggccagcagcctcctccgctggcccagccgacacccctg
ccgcaggtcctggccccacagcccgtggtccccctccagccggttcccccccacctgcca
ccgtacctggctccagcctcccaggtgggggcccccgctcagctgaagcccctccagatg
ccacaggcgcccctgcagccgcttgctcaagtccctccgcagatgcccccgattcctgtt
gtgccccccatcacgcccctggcgggaatcgacggcctccctccggccctcccagacctg
ccgaccgcgactgtgcctcccgtgccaccacctcagtatttctctccagccgtgatcttg
ccgagcctcgctgccccactcccccctgcgtccccagccttgcctctgcaggctgtgaag
ctgccccacccccctggggcgcccctggccatgccctgccggaccattgtgccaaatgca
ccggccactatccccctgctggccgtagccccaccgggcgtggctgccctgtccattcat
tctgccgtggcccagctcccaggccaacctgtgtacccagcggccttcccacagatggcg
cctactgacgtccctccttccccccatcacacggtgcagaatatgagggccacccctcca
cagccggcactgcctccacaacccacactgcccccacaacccgtgctgcccccgcaaccc
acgctgccccctcaacctgtgttgcccccgcaacccacacggccccctcaacctgtgctg
cccccgcaacccatgctgcccccacaacctgtgctgcccccgcagccggcactgcctgtg
cgccctgagcccctccagccccaccttcctgaacaagctgctccagctgctacaccaggg
agccagattctgcttggccacccagctccctatgctgtggacgtcgccgctcaggtcccc
accgtgcctgtgccaccggctgcggtcctctcgccgcctctgccggaagtgctgctgcct
gccgcccctgagctcctgcctcagttccccagctccctggccacggtgtctgcctctgtg
cagagtgtgcccacccagactgccacacttctgccaccagcaaacccaccgctgcctggc
gggcccgggatcgccagcccttgcccaactgtccagctgacggtggaaccagtccaagag
gagcaggcctcacaggacaagccgcccggcctcccgcagagctgtgagagctatggaggt
tctgatgtcacttctggaaaagagctgagtgacagctgtgaaggcgcctttggagggggc
aggctggagggcagggcagcccgaaaacaccaccgcaggtccacgcgtgcgcgctcccgg
caggagagggccagccggccccggcttaccatcttgaacgtgtgcaacactggggacaag
atggtggagtgccagctggagacgcacaaccacaagatggtgaccttcaagttcgacttg
gacggggacgcacccgatgaaattgccacgtatatggtggagcatgactttatcctgcag
gccgagcgggaaacgttcatcgagcagatgaaggatgtcatggacaaggcagaggacatg
ctcagcgaggacacagacgccgaccgtggctccgacccagggaccagcccgccacacctc
agcacctgcggcctgggcaccggggaggagagccgacaatcccaagccaacgcccccgtg
tatcagcagaacgtcctgcacaccgggaagaggtggttcatcatctgtccggtggctgag
caccccgcccccgaggcccctgaatcttcgcccccacttcctctaagctccctgccgcca
gaagccagccaaggtccatgcagggggctcaccctgccctgtctcccatggcgcagagca
gcctgtggggctgtgttcctatccttgttttctgctgaatcagctcagtcaaagcagcct
ccagattcagcgccctataaagaccagctgtcctcgaaggaacaacccagctttctagcc
agtcagcagctcctgagccaggcgggccccagcaaccctcctggggcacccccagcccct
ttggccccctcctcccctcctgtgactgctctgccccaagatggagcagctccagccacc
agcaccatgccagagccagcgtcaggaactgccagccaggcagggggtccagggacacct
caggggctgaccagtgagctcgagacgtctcagccactagcggagactcacgaggccccg
cttgctgtgcagcccctcgtggtgggcctagcaccttgcactccagctccagaggctgcc
tcaaccagggacgccagtgccccaagggagcccctgccacctcctgcacctgagcccagc
ccccacagcgggaccccacagcccgccttgggtcaacctgctcccctgcttcctgccgca
gtgggggccgtcagcctggccacctcccagctcccaagcccacccctggggcccaccgtc
cccccacagccaccctcggccctggagtcggatggggaagggccgccccccagggtgggc
tttgtggacagcaccatcaagagcctggacgagaagctgcggactctgctctaccaggag
cacgtgcccacctcctcagcctcagctgggacccctgtggaggtgggcgacagagacttc
accctggagcccctgagaggggaccagccccgctcagaggtctgcgggggggacctggcc
ctgcccccagtgcctaaggaggcggtctcagggcgtgtccagctgccccagcccttggtg
gagaagtcagaactggcccccactcgaggggccgtgatggagcagggcacgtcctcgtca
atgacagcagagtcgtctcccaggagtatgctaggctatgacagagatggaaggcaggtg
gcctcagactcccatgtggtccccagcgtcccccaggatgtacctgcttttgtgagacct
gcacgtgtggagcccacagacagggatggtggagaagctggagaaagctcggcagagccc
ccgccgagtgacatgggcacagtggggggccaggctagccacccccagacactcggcgct
cgagctttggggtcccctcggaaacgtccagagcagcaggatgtcagctcaccagccaag
actgtgggccgtttctcggtggtcagcactcaggacgagtggaccctggcctccccccac
agcctgagatactctgccccacccgacgtctacctggacgaggccccctccagccccgac
gtgaagctggcagtgcggcgggcgcagacggcctcctccatcgaggtcggcgtgggcgag
cccgtgtccagcgactctggggacgagggccctcgggcgagacccccggtgcagaagcag
gcgtccctgcccgtgagtggcagcgtggctggcgacttcgtgaagaaggccaccgccttc
ctgcagaggccttctcgggccggctcgctgggccccgagacacccagcagggtgggcatg
aaggtccccacgatcagcgtgacctccttccattcccagtcgtcctacatcagcagcgac
aatgattcggagctcgaggatgctgacataaagaaggagctgcagagtctgcgggagaag
cacctgaaggagatctcggagctgcagagccagcagaagcaggagatcgaagctctgtac
cgccgcctgggcaagccactgccccccaacgtgggcttcttccacacggcaccccccact
ggccgccggagaaaaaccagcaagagcaagctgaaggcaggcaagctgctaaatcccctg
gtgcggcagctcaaggtcgtggcctccagcacaggtcacttggctgactccagcagaggc
cctcccgctaaggaccctgcccaagccagtgtggggctcactgcagacagcacgggcctg
agcgggaaggcagtgcagacccagcagccctgctccgtccgggcctccctgtcttcggac
atctgctccggcttagccagtgatggaggcggagcgcgtggccaaggctggacggtttac
cacccaacgtctgagagagtgacctataagtctagtagcaaacctcgtgctcgattcctc
agtggacccgtatctgtgtccatctggtctgccctgaagcgtctctgcctaggcaaagaa
cacagcagtaggtcctccaccagcagcctggccccaggccctgagccaggcccccagccc
gccctgcacgtccaggcgcaggtgaacaacagcaacaacaagaagggtaccttcacggac
gacctgcacaagctggtggacgagtggacgagcaagacggtgggggccgcgcagctgaag
cccacgctcaaccagctgaagcagacccagaagctgcaagacatggaggcccaggcaggc
tgggctgcccctggcgaggcgcgggctatgaccgcacctcgagcaggagtggggatgcca
cgtctgcccccagcgcccggccctctgtccaccacggtcattcccggagccgccccgacc
ctgtccgtgcccacaccagatggcgccctcggaaccgcccggagaaaccaggtgtggttt
ggcctccgagtcccccccaccgcctgctgtgggcacagcactcagccgcgagggggacag
cgggtgggcagcaagactgcttcctttgcggcttcagaccctgttcgctcctag

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (121)   
   KEGG ORTHOLOGY (1)   
   RefGene (114)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (102)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (100)   
DNA sequence (122)   
   RefSeq(nuc) (100)   
   GenBank (11)   
   EMBL (11)   
3D Structure (2)   
   PDB (2)   
Protein domain (3)   
   Pfam (3)   
All databases (358)   

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